|The maiden voyage of Crystal Serenity was on July 7, 2003, 4 days after her christening. It was a 14-day round-trip cruise, departing Southampton and cruising Northern Europe. During her inaugural season, Crystal Serenity held summer cruises in Europe, the Mediterranean Sea, and a transatlantic crossing. It was followed by two Caribbean/Panama Canal voyages and a combined Christmas/New Year Mexican Riviera cruise, round-trip from Los Angeles.
On January 14, 2004, she embarked on her first world cruise; a 106-day voyage departing Los Angeles, which concluded on May 5, in New York City.